Clinicopathologic characteristics of epithelial ovarian tumours in Ile-Ife, Nigeria

  • AO Anjorin unimedthc
  • GO Omoniyi-Esan
  • OO Odujoko
  • AO Anjorin
Keywords: Clinico-pathology, Epithelial Ovarian Tumours, High-grade Serous Carcinoma, Ile-Ife, Ovarian neoplasm


Background:  Epithelial ovarian tumours (EOT) have complex clinicopathologic characteristics and biological behaviours. There are benign, borderline and malignant ovarian tumours and the commonest ovarian tumours in many regions are of epithelial origin. Many studies have described the histomorphological characteristics of the tumours.

Objective: To describe the clinical and histopathological features of epithelial ovarian tumours.

Methods: This was a retrospective review of the histopathology reports of all epithelial ovarian tumours specimens submitted to the Department of Morbid Anatomy and Forensic Medicine, Obafemi Awolowo University Teaching Hospital, Ile-Ife from January 2005 to December 2014. The EOT cases were described in terms of age, clinicopathological characteristics and distribution of histological types.

Results: The frequencies of benign, borderline and malignant EOTs were 41.2%, 3.9% and 54.9% respectively and the patients were aged 23 to 94 years (mean 46.5±2.6 years). The majority of cases were often asymptomatic.

Conclusion: Abdominal swelling was the most common presenting complaint while serous ovarian tumours were the most preponderant histological types.


Khatri R. Clinicopathological analysis of ovarian tumours at Birendra Military Hospital. Med J Shree Birendra Hosp 2010; 10: 26–31.

Sabageh D, Olaofe OO, Sabageh A. An analysis of the clinicopathologic characteristics of ovarian tumors in Ile-Ife, Nigeria. Ann Trop Pathol 2012; 3: 97–104.

Karpathiou G, Chauleur C, Corsini T, Venet M, Habougit C, Honeyman F, et al. Seromucinous ovarian tumor. A comparison with the rest of ovarian epithelial tumors. Ann Diagn Pathol 2017; 27: 28–33.

Nakamura E, Sato Y, Moriguchi S, Yamashita A, Higo T, Asada Y. Ovarian Seromucinous Borderline Tumor and Clear Cell Carcinoma: An Unusual Combination. Case Rep Obstet Gynecol 2015; 2015: 1–5.

Taylor J, Glenn McCluggage W. Ovarian seromucinous carcinoma: Report of a series of newly categorized and uncommon neoplasm. Am J Surg Pathol 2015; 39: 983–992.

Kubeček O, Laco J, Špaček J, Petera J, Kopecký J, Kubečková A, et al. The pathogenesis, diagnosis, and management of metastatic tumors to the ovary: a comprehensive review. Clin Exp Metastasis 2017; 34: 295–307.

Kakushima N, Kamoshida T, Hirai S, Hotta S, Hirayama T, Yamada J, et al. Early gastric cancer with Krukenberg tumor and review of cases of intramucosal gastric cancers with Krukenberg tumor. J Gastroenterol 2003; 38: 1176–180.

Leen SLS, Singh N. Pathology of primary and metastatic mucinous ovarian neoplasms. J Clin Pathol 2012; 65: 591–595.

Hauptmann S, Friedrich K, Redline R, Avril S. Ovarian borderline tumors in the 2014 WHO classification: evolving concepts and diagnostic criteria. Virchows Arch 2017; 470: 125–142.

Avril S. Histopathological markers of treatment response and recurrence risk in ovarian cancers and borderline tumors. Pathologe 2017; 38: 180–191.

Meinhold-Heerlein I, Fotopoulou C, Harter P, Kurzeder C, Mustea A, Wimberger P, et al. The new WHO classification of ovarian, fallopian tube, and primary peritoneal cancer and its clinical implications. Arch Gynecol Obstet 2016; 293: 695–700.

Brown J, Frumovitz M. Mucinous tumors of the ovary: Current thoughts on diagnosis and management. Curr Oncol Rep 2014; 16: 389.

Omoniyi-Esan GO, Olaofe OO, Omonisi AE, Komolafe AO, Fadahunsi O. Histopathological Analysis of ovarian Cancer In Ile-Ife southwest, Nigeria. Niger J Postgrad Med 2011; 4: 15–19.

Buowari D. Ovarian cyst at general hospital Aliero, Nigeria: A one-year review. Trop J Med Res 2009; 13: 433-434.

Tropé CG, Kaern J, Davidson B. Borderline ovarian tumours. Best Pract Res Clin Obstet Gynaecol 2012; 26: 325–336.

Ghartimagar D, Ghosh A, KC G, Ranabhat S, Talwar O. Surface epithelial tumors of ovary - an analysis in a tertiary referral hospital. J Pathol Nepal 2013; 3: 397–402.

Yakasai IA UE, Otubu J, Yakasai IA, Ugwa EA. Gynecological malignancies in Aminu Kano Teaching Hospital Kano: A 3-year review. Niger J Clin Pract 2013; 16: 63–66.

Tuncer ZS, Gunalp S, Aksu T, Ayhan A. Benign epithelial ovarian tumors. Eur J Gynaecol Oncol 1998; 19: 391–393.

Lee-Jones L. Ovary: Epithelial tumors. Atlas Genet Cytogenet Oncol Haematol 2004; 8: 120–138.

Nnadi D. C, Nwobodo E., Tunau K., Malami S. Histo-Pathological features of primary ovarian tumours managed in A Tertiary Hospital, Sokoto. Sahel Med J 2009; 12: 171–174.

Hu A, Li H, Zhang L, Ren C, Wang Y, Liu Y, et al. Differentiating primary and extragenital metastatic mucinous ovarian tumours: an algorithm combining PAX8 with tumour size and laterality. J Clin Pathol 2015; 68: 522–528.

Ackroyd SA, Goetsch L, Brown J, Houck K, Wang C, Hernandez E. Pancreaticobiliary metastasis presenting as primary mucinous ovarian neoplasm: A systematic literature review. Gynecol Oncol Rep 2019; 28: 109–115.

Onyegbule O, Etigbue J, Uyoh I, Ezenri U, Okafor C. Giant mucinous cystadenoma in Nnewi, Nigeria. Ann Med Health Sci Res 2015; 5: 222-225.

Pilone V, Tramontano S, Picarelli P, Monda A, Romano M, Renzulli M, et al. Giant mucinous ovarian borderline tumor. A good lesson from an asymptomatic case. Int J Surg Case Rep 2018; 50: 25–27.

Lerwill MF, Young RH. Mucinous tumours of the ovary. Diagnostic Histopathol 2008; 14: 366–387.

Sangwaiya A, Garg S, Kalhan S, Satarkar R, Singh P, Gill M. Malignant Brenner tumor of ovary: A rare entity. Clin Cancer Investig J 2015; 4: 584-586.

Brenner Tumor B, Zheng R, Heller DS. Resident Short Reviews A Review of the Literature. Arch Pathol Lab Med 2019; 143: 1278–180.

Hiroi H, Osuga Y, Tarumoto Y, Shimokama T, Yano T, Yokota H, et al. A case of estrogen-producing Brenner tumor with a stromal component as a potential source for estrogen. Oncology 2002; 63: 201–204.

Bodurka DC, Deavers MT, Tian C, Sun CC, Malpica A, Coleman RL, et al. Reclassification of serous ovarian carcinoma by a 2-tier system. Cancer 2012; 118: 3087–3094.

Matsuno RK, Sherman ME, Visvanathan K, Goodman MT, Hernandez BY, Lynch CF, et al. Agreement for tumor grade of ovarian carcinoma: analysis of archival tissues from the surveillance, epidemiology, and end results residual tissue repository. Cancer Causes Control 2013; 24: 749–757.

Lisio M-A, Fu L, Goyeneche A, Gao Z, Telleria C. High-Grade Serous Ovarian Cancer: Basic Sciences, Clinical and Therapeutic Standpoints. Int J Mol Sci 2019; 20: E952. doi: 10.3390/ijms20040952.

Shoji T, Takatori E, Murakami K, Kaido Y, Takeuchi S, Kikuchi A, et al. A case of ovarian adenosquamous carcinoma arising from endometrioid adenocarcinoma: a case report and systematic review. J Ovarian Res 2016; 9: 48: 2-7.

Fu YS, Stock RJ, Reagan JW, Storaasli JP, Budd Wentz W. Significance of squamous components in endometrioid carcinoma of the ovary. Cancer 1979; 44: 614–621.

Gilks CB, Irving J, Köbel M, Lee C, Singh N, Wilkinson N, et al. Incidental nonuterine high-grade serous carcinomas arise in the fallopian tube in most cases: Further evidence for the tubal origin of high-grade serous carcinomas. Am J Surg Pathol 2015; 39: 357–364.

Kuhn E, Ayhan A, Shih IM, Seidman JD, Kurman RJ. Ovarian Brenner tumour: A morphologic and immunohistochemical analysis suggesting an origin from fallopian tube epithelium. Eur J Cancer 2013; 49: 3839–349.

Original Research